Non-Hodgkin lymphoma (NHL) is a cancer that begins in lymphocytes. Lymphocytes are the cells of the lymphatic system.
Tipo NHL @(Model.HeadingTag)>
There are over 30 different types in the NHL. They are grouped according to the type of lymphocyte they originate from. Most types of NHL begin in B cells, called B-cell lymphomas. NHL can also start in T cells, called T cell lymphoma. NHL that originates in NK cells is grouped with T-cell lymphomas.
Different types of NHL look different under the microscope. They also develop and grow differently. NHL is classified by how different or abnormal the lymphoma cells are compared to normal lymphocytes. The note gives doctors an idea of how slowly or quickly the NHL is growing and spreading. The NHL is generally divided into 2 levels:
- Indolent (low grade) NHL means that the cancer cells are well differentiated. They look and behave the same as normal cells. These NHLs tend to grow slowly.
- Aggressive (high-grade) NHL means that the cancer cells are poor or undifferentiated. Their appearance and behavior are less than normal or more abnormal. These NHL tend to develop rapidly.
Classification system of the World Health Organization (WHO) @(Model.HeadingTag)>
Doctors use the WHO classification system to identify types of NHL. Each type can present differently and require different treatments.
The WHO classifies NHL by the type of lymphocyte (B cell or T cell) that becomes cancerous. NHLs that begin in natural killer cells (NK cells) fall into the same category as T-cell lymphomas.
The World Health Organization divides B and T cell lymphomas into two categories based on the stage of development or maturation when the lymphocytes become cancerous. Precursor lymphomas form in immature lymphocytes in the early stages of their development. Mature lymphomas (also called peripheral lymphomas) develop in more mature lymphocytes.
The specific type of NHL depends on the appearance of the abnormal lymphocytes or lymphoma cells under the microscope, the characteristics of the chromosomes in the lymphoma cells, and the presence of certain proteins on the surface of the lymphoma cells.
The WHO classifies lymphoma and lymphocytic leukemia as types of NHL. Both begin in lymphocytes, but lymphoma cells are found in different parts of the body. If the tumor develops in the lymph nodes or other organs, it is considered lymphoma. Lymphoma is considered leukaemic lymphoma when lymphoma cells are present in the blood or bone marrow and form a tumor.
Other cancers of the lymphatic system are mentionedHodgkin lymphoma(HL). Abnormal Hodgkin lymphoma cells look and behave differently than non-Hodgkin lymphoma cells. Hodgkin lymphoma and non-Hodgkin lymphoma are treated differently.
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British Columbia Cancer Agency (BCCA).Non-Hodgkin lymphoma. Also 2014:http://www.bccancer.bc.ca/。
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[ PubMed ] Friedman AS, Jacobson CA, Moher P, Aster JC. Non-Hodgkin lymphoma. DeVita VT Jr, Lawrence TS and Rosenberg SA.Cancer: principles and practice of oncology. 10th edition. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015:103:1552-1583.
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The lymphatic system drains excess fluid (called lymph) from the blood into the tissues and returns it to the blood. The lymphatic system is a circulatory system made up of lymph vessels that resemble blood vessels. The lymphatic system also includes the tissues and organs that produce, store, and release lymphocytes (a type of white blood cell).
Learn more about the lymphatic system
diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL. Some other NHL types can also turn into DLBCL. Learn more about DLBCLs.
Learn more about diffuse large B-cell lymphoma
Follicular lymphoma is the second most common type of NHL. There should be no symptoms other than swollen lymph nodes. Learn more about follicular lymphoma.
Learn more about follicular lymphoma
MALT lymphoma is a type of B cell NHL. Most MALT lymphomas begin in the stomach. Learn more about MALT lymphoma.
Learn more about MALT lymphoma
Mantle cell lymphoma is more common in men than in women. The diagnosis is usually made in people over the age of 60. Learn more about mantle cell lymphoma.
Learn more about mantle cell lymphoma
More Types of Non-Hodgkin's Lymphoma
Lymphoma is a cancer that affects a type of white blood cell called a lymphocyte. Lymphocytes are cells of the immune system that normally protect us against disease. Learn more about types of non-Hodgkin lymphoma.
Learn about more types of non-Hodgkin lymphoma
adult T-cell leukemia lymphoma
Learn more about adult T-cell leukemia/lymphoma. It is more common in places where the HTLV-1 virus is more common, such as the Caribbean and parts of Africa.
Learn more about adult T-cell leukemia lymphoma
Aggressive NK cell leukemia
Aggressive NK cell leukemia (ANKL) is a rare form of NHL. It usually occurs in people from Asia, Central and South America. Read more about ANKL.
Read more about aggressive NK cell leukemia
Non-Hodgkin lymphoma is the most common type of lymphoma that affects people with AIDS. Learn about the main types of AIDS-related lymphoma.
Learn more about AIDS-related lymphoma
Anaplastic large cell lymphoma
Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma. ALCL can occur at any age, but is more common in children and young adults. It affects more men than women.
Learn more about anaplastic large cell lymphoma
T-cell angioimmunoblastic lymphoma (ATCL or AITL) is more common in older adults and is associated with the Epstein-Barr virus. Learn more about ATCLs.
Learn more about angioimmunoblastic T-cell lymphoma
Burkitt lymphoma is most common in children and young adults. Most people are infected with the Epstein-Barr virus. Learn more about Burkitt lymphoma.
Learn more about Burkitt lymphoma
Chronic lymphocytic leukemia and small lymphatic lymphoma
Chronic lymphocytic leukemia and small lymphatic lymphoma are often considered different versions of the same disease. Learn more about these NHLs.
Read more about chronic lymphocytic leukemia and small lymphatic lymphoma
Cutaneous T-cell lymphoma (CTCL) is a group of lymphomas that affect the skin. Learn about the symptoms and treatments of different types of CTCL.
Learn more about cutaneous T-cell lymphoma
T-cell lymphoma associated with enteropathy
Enteropathy-associated T-cell lymphoma (ETL) is a very rare form of non-Hodgkin's lymphoma (NHL). The most common types of EATL are associated with celiac disease or gluten sensitivity. Learn more about EATL.
Learn more about enteropathy-associated T-cell lymphoma
Extranodal NK/T cell lymphoma, nasal type
Extranodal NK/T cell lymphoma of the nasal type is a fast-growing type of NHL. It is related to the Epstein-Barr virus. Learn more about these NHLs.
Learn more about nasal extranodal NK/T cell lymphoma
Hepatosplenic T-cell lymphoma (HSTL or HSTCL) is very rare. This sometimes happens in people whose immune system is not working properly. Learn more about HSTL.
Learn more about hepatosplenic T-cell lymphoma
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Intravascular large B-cell lymphoma (ILCL) is a fast-growing type of NHL. It is usually treated with chemotherapy and targeted therapy. Learn more about ILCLs.
Learn more about intravascular large B-cell lymphoma
Lymphoblastic lymphoma is most common in teens and young adults. They are more common in young men. Learn more about lymphoblastic lymphoma.
Learn more about lymphoblastic lymphoma
Lymphoplasmacytic lymphoma cells have characteristics of both lymphocytes and plasma cells. Learn more about lymphoplasmacytic lymphoma.
Learn more about lymphoplasmacytic lymphoma
Marginal lymph node lymphoma
Nodal lymphoma in the marginal zone usually affects only the lymph nodes, but can develop in other organs as well. Learn more about marginal zone lymphoma.
Learn more about marginal nodal zone lymphoma
Peripheral T-cell lymphoma, unspecified
Peripheral T-cell lymphoma, unspecified (PTCLU) usually occurs in people in their 60s, more men than women. Learn more about PTCLUs.
Learn more about unspecified peripheral T-cell lymphoma
Lymphoproliferative disorder after transplantation
Post-transplant lymphoproliferative disorder (PTLD) is a complication that can occur after organ transplantation. Learn more about PTLDs.
Learn more about post-transplant lymphoproliferative disease
primary lymphoma of the central nervous system
Primary central nervous system lymphoma (PCNSL) begins in the brain, spinal cord, meninges, or eyes. Learn more about primary central nervous system lymphoma.
Learn more about primary central nervous system lymphoma
primary effusion lymphoma
Primary effusion lymphoma (PEL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). It is also considered a separate type of non-Hodgkin lymphoma (NHL) in the World Health Organization (WHO) classification system. PEL may also be called body cavity lymphoma.
Learn more about primary stroke lymphoma
Primary mediastinal large B-cell lymphoma
Primary mediastinal large B-cell lymphoma (PMBCL) occurs in the thymus or lymph nodes in the center of the chest. Learn more about PMBCLs.
Learn more about primary large B-cell lymphoma of the mediastinum
Prolymphatic leukemias (PLLs) are rare lymphocytic leukemias, but also resemble lymphomas in that they begin in lymphocytes. Learn more about PLLs.
Learn more about prolymphatic leukemia
Spleen marginal zone lymphoma
Splenic marginal zone lymphoma (SMZL) is a slow-growing type of NHL. It has been linked to viral infections, including the hepatitis C virus. Learn more about SMZLs.
Learn more about splenic margin zone lymphoma
Panniculitis-like subcutaneous T-cell lymphoma
Panniculitis-like subcutaneous T-cell lymphoma (SPTCL) causes nodules under the skin of the legs, chest, abdomen, or back. Learn more about SPTCLs.
Read more about panniculitis-like subcutaneous T-cell lymphoma
T-cell large granular lymphocytic leukemia
Large granular T-cell lymphocyte (TLGL) leukemia is common in people with rheumatoid arthritis or other autoimmune diseases. Learn more about TLGL leukemia.
Learn more about T-cell large granular lymphocytic leukemia